Toll-Like Receptors: Role in Dermatological Disease

Toll-Like Receptors: Role in Dermatological Disease

Toll-like receptors (TLRs) are a class of conserved receptors that recognize pathogen-associated molecular patterns (PAMPs) present in microbes. In humans, at least ten TLRs have been identified, and their recognition targets range from bacterial endotoxins to lipopeptides, DNA, dsRNA, ssRNA, fungal products, and several host factors. Of dermatological interest, these receptors are expressed on...

The Role of Toll-Like Receptors in Breast Cancer

Breast cancer is highly prevalent worldwide. Treatment of this disease is a major global public health problem; therefore, numerous studies have explored new molecular profile helping for breast cancer therapy. Different risk factors are attributed to breast cancer; however, chronic inflammation and immune regulation are highly essential. Various molecules impact this context, including toll-li...

The Role of Toll Like Receptors in Pregnancy

the role of toll-like receptors in pain control

the toll like (family of receptors tlr) are expressed primarily by immune cells and are known to be part of innate immune system. in the past decade involvement of tlrs in several physiologic and pathologic pathways has been proved. pain transmission via glial activation is one of such interesting fields. both pathological pain states and treatment have also been shown to be related to tlr-rela...

role of toll-like receptors in tuberculosis infection

background one-third of the world’s population is infected with mycobacterium tuberculosis. investigation of toll-like receptors (tlrs) has revealed new information regarding the immunopathogenesis of this disease. toll-like receptors can recognize various ligands with a lipoprotein structure in the bacilli. toll-like receptor 2 and tlr-4 have been identified in association with tuberculosis in...